Intranasal administration of dantrolene increased brain concentration and duration

[Possibility of therapy of brain functions by intranasal administration].

Preferential brain homing following intranasal administration of Trypanosoma cruzi.

The Chagas' disease parasite Trypanosoma cruzi commonly infects humans through skin abrasions or mucosa from reduviid bug excreta. Yet most studies on animal models start with subcutaneous or intraperitoneal injections, a distant approximation of the skin abrasion route. We show here that atraumatic placement of T. cruzi in the mouse nasal cavity produced low parasitemia, high survival rates, a...

Intranasal administration of drugs.

OBJECTIVE To investigate how nasally applied substances distribute in the nose depending on the form of application. DESIGN Observer-blinded study. SETTING University hospital research unit. PARTICIPANTS Fifteen healthy volunteers aged 22 to 32 years. INTERVENTIONS Forms of application included (1) nasal drops applied with a pipette, (2) nasal spray, and (3) a system producing squirts. ...

Accumulation of manganese in rat brain following intranasal administration.

Manganese chloride (50-800 micrograms) was injected unilaterally into the right nostril of rats and its accumulation in the central nervous system (CNS) was monitored. Brain manganese levels were elevated in a dose-dependent, time-dependent, and tissue-dependent manner. Elevated levels of manganese were detected in the right olfactory bulb and olfactory tubercle within 12 hr after instillation ...

Pharmacokinetics of baicalin-phospholipid complex in rat plasma and brain tissues after intranasal and intravenous administration.

The aim of this study is to determine whether baicalin can be transferred along the olfactory pathway to the brain after nasal administration of baicalin phospholipid (BP) complex to rats, thereby circumventing the blood brain barrier. The concentration of baicalin in plasma and different brain tissues (olfactory bulb, cerebral cortex, striatum and cerebellum) were measured by high-performance ...